No, if pitches are the same letter and in the same register they will sound the same. The note D printed as sitting on top of a leger line above the bass cleff on the grand staff has the same sound as a D printed below the bottom line of the treble clef on the grand staff.
Explanation:
The note D printed as sitting on top of a leger line above the bass cleff on the grand staff has the same sound as a D printed below the bottom line of the treble clef on the grand staff.