Isolation
I put indifference as said below and I got it wrong
This is something u need to look for in your book
The first Europeans to purchase furs from Indians were French and English fishermen who, during the 1500s, fished off the coast of northeastern Canada and occasionally traded with the Indians. In exchange, the Indians received European-manufactured goods such as guns, metal cooking utensils, and cloth.
September 17 1787 is the answer