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OBJECTIVES: To analyze the occurrence and types of neoplasias that have developed in patients submitted to orthotopic heart transplantation in the Cardiac Transplantation Program of the Paulista School of Medicine, Federal University of São Paulo.
METHODS: The present study presents an observational analysis of 106 patients submitted to orthotopic heart transplantation from November 1986 to September 2002, who survived for more than 30 days after the procedure. The immunosuppressive regimen consisted of triple therapy with cyclosporin A, azathioprine and corticosteroid. Only two patients received, in addition to triple therapy, the addition of orthoclone OKT-3. The mean follow-up period was 61.4 months. (variation from two months to 192 months).
RESULTS: Twenty-three patients (21.3%) developed neoplasias, of which 56.5% had skin neoplasms, 30.1% had solid tumors and 13.4% had post-transplantation lymphoproliferative disease (PTLD). The mean interval between transplantation and the diagnosis of neoplasia was: skin - 54.9 months, solid tumors - 24.8 months and DLPT - 70.3 months.
CONCLUSIONS: The occurrence of malignant neoplasms was relatively common in the analyzed population. Skin cancer prevailed in relation to other neoplasms and solid tumors were more diagnosed than lymphoproliferative diseases in this series of patients.
Kodak Black, young prodigy. hope this helps
One of the benefits of asexual reproduction is that only individual parents are demanded. When the living thing is prepared to generate offspring, it could do so accordingly without procrastinating for a sufficient comrade.
Answer:
1) We took a taxi to the stadium <u>lest</u> we get late for the game.
2)<u>Although</u> Daniel was a wise man, the king did not trust him.
3)He took his mother to the doctor <u>as soon as</u> he got his first salary>
4)<u>Neither</u> the teacher <u>nor</u> the boys are going for the picnic.
5) You will never progress in life <u>unless </u>you change your attitude