The biggest factors would be food and water.
Freedom of Slavery as the south slavery plantations were vital to the souths economy and tarrifs
A drawing by Leonardo Davinci
Thomas Jefferson was concerned about the Louisiana purchase as the land was unexplored as Louis and Clark had only gone through a small section of the land. Also the land would add a lot of land for the United States witch was still developing as a country so that means that it could be left useless and unexplored and no people could live there
