Because it is easily accessible and has a mild immune response, the retina makes a good target for gene therapy.
- In a mouse model, the inner retina was highly effectively transduced by an intravitreally injected adeno-associated virus (AAV) vector.
- The vitreous and internal limiting membrane (ILM) operated as obstacles to transduction in large animals, reducing the efficacy of retinal transduction.
- Before administering AAV vectors, we performed vitrectomy (VIT) and ILM peeling on cynomolgus monkeys to get around these obstacles.
- The findings suggest that surgical ILM peeling prior to AAV vector delivery would be beneficial for retinal disease treatment and safe for effective transduction of the nonhuman primate retina.
Learn more about the adeno-associated virus (AAV) with the help of the given link:
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Studies of the similarity of the DNA in wasps and bees suggest that the first bees appeared about 130 million years ago, 50 million years before the first known fossil bee, and probably very shortly after the first flowers evolved in the Cretaceous.
A cell wall is missing in archbacteria and euacteria
It depends on her position. If she is a batter, then power would be the answer. If she was a pitcher, then balance.
