Several hours after your last meal, declining blood glucose levels stimulate release of the hormone <u>glucagon</u> , which stimulates glycogenolysis, lipolysis and fat mobilization, and gluconeogenesis.
<h3>How does glucagon stimulate gluconeogenesis?</h3>
The biological process through which glycogen degrades into glucose and glucose-1-phosphate is known as glycogenolysis. Hepatocytes and myocytes both participate in the response. Two important enzymes, glycogen phosphorylase and phosphorylase kinase, control the process.
By increasing the activity of hepatic adipose triglyceride lipase, intrahepatic lipolysis, hepatic acetyl-CoA content, and pyruvate carboxylase flux, as well as increasing mitochondrial fat oxidation, glucagon stimulates hepatic gluconeogenesis. All of these actions are mediated by stimulation of the inositol kinase.
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