A recent study of a model organism found that a specific HMG protein localized mainly to the ends of chromosomes. Given this result, the site of localization for this HMG protein would correspond to regions in humans that Contain heterochromatin similar to that of centromeres.
Telomeres are regions at chromosomal ends that are time and again truncated with every round of the cellular department. Centromeresjoin sister chromatids and are required for correct chromosome division for the duration of mitosis.
Notwithstanding their different chromosomal locations, each telomere and centromere are composed of heterochromatin, a tightly condensed complex of DNA wrapped around histones.
Due to its structurally restrictive form, heterochromatin is transcriptionally inactive, which means that proteins liable for regulating gene expression can't get entry into the tightly packed DNA. As an end result, hetechromatic regions are often gene-bad and incorporate repetitive DNA.
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