Alexander spreaded communication between East and West. Greek ideas and culture.
(hope this is what you are looking for.)
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cave paintings
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The earliest known visual art dates to the middle stone age in the form of a red ochre cave drawing: https://en.wikipedia.org/wiki/Prehistoric_art
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Smooth muscle is non-striated, although it contains the same myofilaments they are just organized differently.
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Answer:
Urban areas doubled, tripled, or quadrupled in size which led to over crowding in cities. Sometimes a large population is a good thing, but in this case the population was too big and caused many health problems.
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