Single-cell damagenome profiling unveils vulnerable genes and functional pathways in human genome toward DNA damage

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We report a unique unmarried-cellular complete-genome amplification method (LCS-WGA) which could correctly seize spontaneous DNA damage existing in single cells. We discuss with those harm-related single-nucleotide editions as "damSNVs," and the entire-genome distribution of damSNVs because the damagenome.

We discovered that during unmarried human neurons, the damagenome distribution turned into significantly correlated with three-dimensional genome structures.

This nonuniform distribution shows extraordinary ranges of DNA harm effects on special genes. next, we identified the functionals that have been considerably enriched within the excessive-damage genes.

comparable functionals had been also enriched in the differentially expressed genes (DEGs) detected by unmarried-mobile transcriptome of both Alzheimer's sickness (advert) and autism spectrum disorder (ASD). This result can be defined with the aid of the sizeable enrichment of excessive-harm genes in the DEGs of neurons for both ad and ASD. the discovery of excessive-harm genes sheds new lighting fixtures on the critical roles of DNA harm in human sicknesses and issues.

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