Question

Single nucleus profiling of human dilated and hypertrophic cardiomyopathy Chaffin et al. (Ellinor); Nature

Answer 1

Dilated cardiomyopathy is a heart disease which causes the heart chambers to thin and stretch , growing larger. It make it harder for the heart to pump blood to the rest of the body.

Extensive molecular alteration is failing heart at single cell resolution by single nucleus RNA which is nearly 600,000 nuclei in left .It occurs when heart's blood pumping Chambers's chambers enlarge or dilated. It occurs because the heart's walls became thickened , which makes it harder for the heart to pump blood.

when hypertrophy cardiomyopathy , ventricles size remains normal and thickening of the walls may block blood flow out of ventricles. This happen by progressing to dilated cardiomyopathy is rare.

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