Question

Used in combination with analgesic agents, medications such as tricyclic antidepressant drugs, benzodiazepine drugs, antiepileptic drugs, and local anesthetic agents may be used for what purpose?

Answer 1

These are used as Potentiate pain relief.

Medications that might possibly affect painful symptoms including opioid analgesics, anticonvulsants , tricyclic antidepressants, capsaicin, benzodiazepines and skeletal muscle relaxants were gradually withdrawn during the study‐washout period. Paracetamol was allowed as rescue medication.

Tricyclic antidepressants are the most common type of antidepressant used for pain.  These antidepressants inhibit the reuptake of serotonin and norepinephrine at the synapse, but do so differentially according to chemical structure.

How Antidepressants Work in Pain Management?

The explicit way in which antidepressants are effective in pain management remains unknown, but multiple mechanisms are likely to be involved.

Perhaps the most popular theory is that antidepressants exert their effects on serotonin and norepinephrine, particularly along the descending spinal pain pathways. Antidepressants may also exert adjunctive therapeutic influences through histamine receptors as well as modulation of sodium channels.

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