Genetic mutations are the alterations of genetic materials. <u>Fatal familial insomnia</u> is a disorder, caused by a genetic mutation, involving a progressive inability to sleep.
<h3>What is fatal familial insomnia?</h3>
Fatal familial insomnia is a brain disorder that can be inherited and affects the sleep cycle. It is a neurodegenerative disease that leads to mental and physical deterioration because of a lack of sleep.
FFI is caused by a genetic mutation in the PRNP gene that alters the mechanism of the thalamus resulting in an alteration of the sleep activity that leads to exhaustion.
Therefore, <u>fatal familial insomnia</u> is the correct blank.
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