The answer is True. The largest and most significant urban center of the Mississippian culture was Cahokia.
A pre-Columbian Native American metropolis can be found right across the Mississippi River from present-day St. Louis, Missouri, at the Cahokia Mounds State Historic Site. Between East St. Louis and Collinsville in southwest Illinois sits this historic park. There are around 80 man-made mounds in the 2,200-acre park, but the old city was much bigger. The city had over 120 earthworks in a variety of sizes, styles, and purposes during its height, circa 1100 CE, when it encompassed roughly 6 square miles.
The Mississippian culture, which advanced cultures across most of what is now the Central and Southeastern United States, began more than 1,000 years before European contact, had its largest and most significant urban colony at Cahokia.
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