1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
My name is Ann [436]
2 years ago
12

cellular flice-inhibitory protein (cflip) isoforms block cd95- and trail death receptor-induced gene induction irrespective of p

rocessing of caspase-8 or cflip in the death-inducing signaling complex.
Biology
1 answer:
solmaris [256]2 years ago
6 0

Death receptors (SDRs) result in apoptosis however additionally stimulate proinflammatory "non-apoptotic" signaling (e.g. NF-κB and mitogen-activated protein kinase (MAPK) activation) and inhibit awesome steps of DR-activated maturation of procaspase-8. To take a look at whether or not isoforms of cellular FLIP (cFLIP) or its cleavage products differentially regulate DR signaling, we mounted HaCaT cells expressing cFLIP(S), cFLIP(L), or mutants of cFLIP(L) (cFLIP(D376N) and cFLIP(p43)). cFLIP editions blocked TRAIL- and CD95L-induced apoptosis, but the cleavage pattern of caspase-8 in the dying inducing signaling complicated was different: cFLIP(L) brought on the processing of caspase-8 to the p43/41 fragments irrespective of cFLIP cleavage. cFLIP(S) or cFLIP(p43) blocked procaspase-8 cleavage. Analyzing non-apoptotic signaling pathways, we found that TRAIL and CD95L activate JNK and p38 within 15 min. cFLIP variations and exclusive caspase inhibitors blocked late demise ligand-induced JNK or p38 MAPK activation suggesting that these responses are secondary to mobile death. cFLIP isoforms/mutants also blocked dying ligand-mediated gene induction of CXCL-8 (IL-8). Knockdown of caspase-8 completely suppressed apoptotic and non-apoptotic signaling. Knockdown of cFLIP isoforms in most important human keratinocytes improved CD95L- and TRAIL-induced NF-κB activation, and JNK and p38 activation, underscoring the regulatory position of cFLIP for these DR-mediated signals. Whereas the presence of caspase-8 is fundamental for apoptotic and non-apoptotic signaling, cFLIP isoforms are strong inhibitors of TRAIL- and CD95L-induced apoptosis, NF-κB activation, and the late JNK and p38 MAPK activation. cFLIP-mediated inhibition of CD95 and TRAIL DR could be of necessary importance for the duration of keratinocyte skin carcinogenesis and the activation of innate and/or adaptive immune responses induced using DR activation in the skin.

Any of two or greater functionally comparable proteins that have a similar but not same amino acid sequence and are either encoded by means of extraordinary genes or with the aid of RNA transcripts from the identical gene which have had special exons removed.

Learn more about isoforms here:

brainly.com/question/17272676

#SPJ4

You might be interested in
In recent years, there has been controversy among biologists about whether Neanderthals should be placed within the same species
Natali [406]

Answer:

The correct answer would be - biological species concept.

Explanation:

The biological species concept is a concept of speciation or how a species forms in nature. According to this, a species is the group of the population that can naturally or potentially interbreed with each other, not on the basis of their physical similarities or habitats.

The physical appearance could be useful as recognizing a species but not defining it. As neanderthals show very little or no gene flow with a modern human it means they do not belong to the same species as modern homo sapiens.

Thus, the correct answer is- biological species concept.

4 0
3 years ago
Protists are very diverse, and many different classification schemes have been used to define relationships between the protists
mars1129 [50]
By using both of these schemes, energy source and locomotion, amoeboids can be classified properly. Both schemes play an important part of amoeboid’s taxonomy classification because these organisms changes its shape when feeding. Amoebas are traditionally classified under sub-phylum Sarcodina, single-celled with pseudopods (use for locomotion) but recent studies show that they are not monophyletic and actually belong to other groups of organisms — with locomotion and source of nutrients as basis.
5 0
3 years ago
How are thorns and spines related to drought resistance?
Tresset [83]

Answer:

To survive in drought conditions, plants need to decrease transpiration to limit their water loss. Some plants that live in dry conditions have evolved to have smaller leaves and therefore fewer stomata. Extreme examples are plants with leaves that resemble spiky thorns or spines.

7 0
3 years ago
Maltase is an enzyme that breaks down the disaccharide maltose into glucose molecules. The reaction usually takes place at a pH
nekit [7.7K]
I think the correct answer from the choices listed above is option A. If the reaction of maltase is optimum at the pH range of 6 to 7, then most likely when the ph is decreased into three maltase would not be able to function outside of its optimal pH range. Hope this answers the question.
6 0
3 years ago
Read 2 more answers
An X-linked recessive gene produces red-green color blindness in humans. A woman with normal color vision whose father was color
dalvyx [7]

Answer:

50% chance

Explanation:

If the woman's father was color blind then that means that he has the recessive gene on his X chromosome. The Y chromosome does not carry this trait. Now, she has inherited on of her mother's X chromosome and her father's recessive gene on the only X chromosome that he can provide. Since she is not color blind she has inherited a normal/dominant trait from her mother as well. Her male offspring will inherit either one normal or one recessive. So in this case there is a 50% chance of being a color blind male.

6 0
3 years ago
Other questions:
  • Thick skin has a more extensive dermal layer than thin skin. thick skin has a more extensive dermal layer than thin skin.
    10·1 answer
  • Scientist believe that the function of a hiccup in the human body could be all of the following except for:
    5·1 answer
  • What responses are observed in a person experiencing acidosis, a condition defined by the ph of the blood falling below 7.4?
    11·1 answer
  • What would be the first thing you would do if you are burned by a chemical while performing a man experiment
    13·1 answer
  • How would you break the carbohydrate protein and lipid molecules apart?
    10·1 answer
  • Cellular respiration is the oxygen dependent process through which food molecules are broken down and the energy released used t
    9·1 answer
  • Which two words are the closest antonyms?
    13·1 answer
  • PLEASE ANSWER FAST I NEED ANSWER
    8·1 answer
  • Help with these two questions, porfavor! :'/
    14·2 answers
  • Help pls will give brainliest
    14·2 answers
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!