Contaminated lands and environments cause health difficulties such as cancer, can effect the respiratory system, and problems on the skin.
The correct answer is the final option - sickle cell disease and malaria are both potentially lethal diseases.
The other options are incorrect because sickle cell disease is an inherited disease, but malaria is not - it is an infectious disease. However, both of these disease are quite dangerous, and may have severe consequences (such as death) if they are not properly treated.
BMI is used mostly to determine the fat ratio compared to your body weight and height.