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SSSSS [86.1K]
1 year ago
11

Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia

Biology
1 answer:
GuDViN [60]1 year ago
5 0

Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.

Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.

Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.

Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.

Learn more about mutations here : brainly.com/question/17031191

#SPJ4

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The enzyme that catalyzes the fixation of carbon dioxide in photosynthesis is _____. See Section 10.4 (Page 224) . View Availabl
olasank [31]
<h2>Answer is "RuBisco"</h2>

Explanation:

  • It contains high measures of fundamental amino acids, which makes it somewhat interesting among vegetable proteins. Because of its properties, RuBisCo is a generally excellent possibility for food applications. It can not exclusively be utilized as a protein source yet in addition as an emulsifier, frothing and gelling operator
  • RuBisCO, and it is a type of protein, called an enzyme, that is involved in the Calvin cycle.An enzyme is a type of protein that makes reactions occur faster. For example, there is an enzyme in our body that helps transfer carbon dioxide from our cells to our blood. This reaction occurs 107 times faster with the enzyme
  • Hence, the right answer for fill up the blanks is "RuBisco"

4 0
3 years ago
The adaptive advantage of a fungus producing and secreting a bacterial inhibitor would be that it protects against microbial com
Advocard [28]

The adaptive advantage of a fungus producing and secreting a bacterial inhibitor would be that it protects against microbial competitors: is an extensive surface area well suited for invasive growth and absorptive nutrition.

Fungus

A fungus is any eukaryotic organism that includes microbes like yeasts and moulds, as well as the more recognisable mushrooms. These organisms are classed as a kingdom distinct from the other eukaryotic kingdoms, which include Plantae, Animalia, Protozoa, and Chromista in one traditional taxonomy.

The presence of chitin in fungi's cell walls distinguishes them from plants, bacteria, and some protists. Fungi, like animals, are heterotrophs; they obtain nourishment by absorbing dissolved molecules, usually by secreting digestive enzymes into their surroundings.

Fungi, like plants, use chemical defence, which involves the creation of poisons that affect the growth, development, or viability of the antagonists.

To learn more about fungus

brainly.com/question/10878050

#SPJ1

5 0
1 year ago
Scenario 1:
Vedmedyk [2.9K]

Answer:

Yes.

Explanation:

Yes, this type of genetic engineering should be pursued in order to avoid decrease in death through infections or diseases as well as increase the production of milk and meat of that animals. With this genetic engineering, organisms have high resistance to diseases which decrease the cost of antibiotics. The positive effect of this genetic engineering is the increase in the resistance that leads to good health as well as productivity of organism.

3 0
3 years ago
A pulley system has an mechanical advantage of 10. If a mover used this pulley to lift a piano with a force of 1500 N a distance
Jlenok [28]
Answer:
(a) 145 N
(B) 40 N
(c) 10 ropes
Explanation:
Mechanical advantage, where and are input and output force respectively
Since MA is given as 10 and input force is 1450 N

Therefore, the mover must use a force of 145 N
(b)
Since also and the is given as 4 m then

(c)
Literally, we need 10 rope segments to support the piano since we utilize the mechanical advantage
3 0
3 years ago
A P E X help now plz!
PSYCHO15rus [73]

Answer:

Explanation:

its D brain list pweaseee

6 0
3 years ago
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