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Volgvan
1 year ago
10

One of the most dramatic recent developments in prehospital emergency care is the use of a(n):_____.

Medicine
1 answer:
Rus_ich [418]1 year ago
3 0

the most dramatic recent developments in prehospital emergency care is the use of AUTOMATED EXTERNAL DEFIBRILLATOR

<h3>What is AUTOMATED EXTERNAL DEFIBRILLATOR?</h3>

The use of electricity to stop an arrhythmia and restore the heart's normal rhythm is known as defibrillation. An automated external defibrillator (AED) is a portable electronic device that can automatically diagnose the life-threatening cardiac arrhythmias ventricular fibrillation (VF) and pulseless ventricular tachycardia.

AEDs are created to be user-friendly for laypeople, with straightforward audio and visual directions, and the use of AEDs is covered in many first aid, certified first responder, and basic life support (BLS) level cardiopulmonary resuscitation (CPR) training. Frank Pantridge created the portable defibrillator in Belfast, Northern Ireland, in the middle of the 1960s, and the Cardiac Resuscitation Company created the first automatic defibrillator for use in public in the late

To learn more about AUTOMATED EXTERNAL DEFIBRILLATOR from the link:

brainly.com/question/3079443

#SPJ4

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Okay

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Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’

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