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aleksandr82 [10.1K]
1 year ago
9

Somatic hypermutation occurs only in the ________ regions of rearranged heavy and light chains.

Biology
1 answer:
babunello [35]1 year ago
5 0

somatic hypermutation occurs only in the <u>V or Variable</u> regions of rearranged heavy and light chains.

Somatic hypermutation occurs only in activated B cells, not T cells. This occurs in germinal establishments inside of lymph nodes and the spleen, where B cells are stimulated and T cells are present. Somatic hypermutation is a procedure in which point mutations pile up at rates 106-fold greater than the background mutation rates observed in other genes in the antibody V-regions of both the light and heavy chains.

Somatic hypermutation of immunoglobulin (Ig) genes is important in antibody-mediated immunity. SHM in B cells serves as the molecular foundation for antibody affinity maturation. In this way, SHM plays an important role in optimizing antibody-dependent immune responses.

For more information on Somatic hypermutation, visit :

brainly.com/question/16349768

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Here's what I get  

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