The most effective way to demonstrate Russell and Burch's substitute approach is to substitute animals in an experiment with computer modeling software.
<h3>What do Russell and Burch mean by the three Rs in animal use?</h3>
In their book "The Idea of Humane Experimental Technique," two English scientists, Russell and Burch, introduced the Three Rs principle in the early 1960s. Replacement, Reduction, and Refinement are referred to as the 3 Rs.
<h3>What does animal research replacement look like?</h3>
Full/Absolute Replacement totally forgoes the use of animals. Training mannequins, biological cells and tissues computer simulations, and micro physiological systems are a few examples.
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