The peripheral chemoreceptors are the quick-response blood pressure sensors found in the carotid bodies at the common carotid artery's bifurcation.
Modifications in the partial pressure of oxygen activate peripheral chemoreceptors, which then cause respiratory drive changes aimed at maintaining normal partial pressure levels.
Peripheral chemoreceptors have been shown in studies on fetal lambs to be functionally active and can be triggered by further lowering the already low fetal PaO2.
The peripheral chemoreceptors, which respond more quickly, notice changes in the peripheral environment, whereas the central chemoreceptors adjust respiration depending on variations in CO2/pH sensed in the brain. About two thirds of the ventilatory response to CO2/pH is caused by central chemoreceptor sites.
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