The absence of nucleosomes in a section of the genome is known as a nucleosome-free region (NFR). They are frequently located at the start and end of genes.
The repeating unit in eukaryotic chromatin that resembles beads on a thread is called a nucleosome. There are roughly 150 base pairs of DNA in one nucleosome. DNA packaging is carried out by eukaryotic cells to fit the lengthy DNA strands into each cell's nucleus. The system is constructed by wrapping DNA around eight histone protein cores.
It is believed that an NFR at the start of a gene is crucial for gene activation. A gene's correct termination may depend on the NFR at its terminus.
A nucleosome on a promoter stops transcription from starting. Thus, the nucleosome functions as a repressor of all transcription in addition to being a general gene repressor.
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