At the outbreak of the war, for example, the majority of the Cherokees sided with the Union, but soon after allied with the Confederacy. Native Americans fought knowing they might jeopardize their sovereignty, unique cultures, and ancestral lands if they ended up on the losing side of the Civil War.
This is true because the countries all wanted to be more wealthy since wealth=strength
Land trade would become more important and lead to the caravan industry and a thriving trade based economy.
Well, the Trail of Tears was a government ordered exile of the Native Americans in most of the South, so this would mean that the Cherokee traveled the farthest on the Trail of Tears.