You can consider it to be Isolated. The doctrine was about preventing anyone from Europe from participating in political activities in the new land, and it was proclaimed that any European force that tried to control or colonize countries in the new land would be considered to be unfriendly to the US and the US would help the countries under attack.
The fourth one is the best one to choose go for it
A. It became a trading center due to its location and size.
It is the Ishtar Gate, built by Nebuchadnezzar II
