Answer:
Abstract
Down syndrome (DS) is associated with aberrations in genetic, morphological, biochemical and physiological characteristics. A number of genes located on human chromosome 21 (HSA21) encode proteins which are thought to be involved in numerous metabolic pathways, e.g., phosphofructokinase, cystathionine β-synthase etc. Perturbations of the metabolic pathways may lead to altered drug metabolism in DS individuals. We present a review of metabolic aberrations linked to HSA21 genes in DS. We particularly focus on drug disposition, efficacy, sensitivity and toxicity of anti-leukaemic agents including methotrexate, glucocorticoids, anthracyclines and cytarabine in DS leukaemia. The different outcomes of therapy due to differential drug response, varied drug toxicity and treatment related mortality in DS leukaemia is a subject of much research and speculation. Altered drug response in DS individuals may stem from differences in pharmacokinetics, pharmacodynamics and pharmacogenetics. Further large-cohort studies in different age groups dissecting metabolic and molecular pathways involved in drug response may increase our understanding in this regard and stipulate pharmacotherapies in DS.
Answer:
A male's skeleton is usually thicker, rougher and appears more bumpy. ○ Due to the fact that males have larger muscles and therefore their skeletons require stronger attachment sites. Women who have borne children have scars on the surface of their pelvis. The femur (thigh bone) of a male is thicker than a females.
The correct answer for this question is "all of the above." Organic farming practices relate to soil health includes: relying on soil health for good crop production, relying on the interaction between soil microbes and organic matter and avoiding the use of pesticides and chemicals.
An isotonic solution requires the same osmotic pressure as the solution to which it is compared. For example in an isotonic saline solution the concentration of sodium chloride is such that it requires the same osmotic pressure as human blood. If comparing two solutions with the same components, this means that the concentration of solute is equal in both solutions.
A hypertonic solution requires a higher osmotic pressure than the solution to which it is compared. If comparing two solutions with the same components, this means that the concentration of solute is higher than that of the other solution.
Answer:
D
Explanation:
The chimicals pollutes the water with toxins
