The answer would be Europe
There were many religious wars during this time. I'll give you one example. The 30 years war. It was one of the longest wars during this time.
Bubonic plague had a recent outbreak i India so definitely B and E are false.
It never really reached Africa to a great extent, so C is also false
Now we have D and A , and A is correct because bubonic plague originated in Eastern Asia, not in Europe.