Question

A nucleosome forms hydrogen bonds with what part of the DNA? A nucleosome forms hydrogen bonds with what part of the DNA? only with bases via the minor groove only with bases via the major groove with the phosphodiester backbone and with bases via the major groove with the phosphodiester backbone and with bases via the minor groove

Answer 1

Answer:

With the phosphodiester backbone and with the bases via the minor groove

Explanation:

Nucleosomes form hydrogen bonds with the DNA to allow for the compacting of the DNA in eukaryotic cells. The nuceosomes consists of histone octamer surrounded by several base pairs wrapped in an helical manner.

The DNA interacts with the nucleosomes via it's histone octamer; the minor groove of that DNA bonds with the base pairs of that nucleosomes mostly the A:T base pairs more than the G:U; the phosphodiester backbone of the DNA.

Answer 2

Answer:

The correct answer is: D) with the phosphodiester backbone and with the bases via the minor groove .

Explanation:

In eukaryotes, nucleosomes are the basic structural unit of packaged DNA. The nucleosome consists of a histone octamer that is wrapped by the DNA strands. This structure is key to compact the extremely long DNA molecule.

In order to achieve this structure, the nucleosome forms hydrogen bonds with the DNA: the hydrogen from the histone-fold bonds with both the A:T rich bases and the phosphodiester backbone.