This was caused by the bubonic plague also known as the 'black death'.Disease from flies that were on rats cause the population to wipe out.
what are you asking exactly?
When Newton was three, his mother remarried and went to live with her new husband, the Reverend Barnabus Smith, leaving her son in the care of his maternal grandmother, Margery Ayscough. The young Isaac disliked his stepfather and held some enmity towards his mother for marrying him
