OBJECTIVES: To analyze the occurrence and types of neoplasias that have developed in patients submitted to orthotopic heart transplantation in the Cardiac Transplantation Program of the Paulista School of Medicine, Federal University of São Paulo.
METHODS: The present study presents an observational analysis of 106 patients submitted to orthotopic heart transplantation from November 1986 to September 2002, who survived for more than 30 days after the procedure. The immunosuppressive regimen consisted of triple therapy with cyclosporin A, azathioprine and corticosteroid. Only two patients received, in addition to triple therapy, the addition of orthoclone OKT-3. The mean follow-up period was 61.4 months. (variation from two months to 192 months).
RESULTS: Twenty-three patients (21.3%) developed neoplasias, of which 56.5% had skin neoplasms, 30.1% had solid tumors and 13.4% had post-transplantation lymphoproliferative disease (PTLD). The mean interval between transplantation and the diagnosis of neoplasia was: skin - 54.9 months, solid tumors - 24.8 months and DLPT - 70.3 months.
CONCLUSIONS: The occurrence of malignant neoplasms was relatively common in the analyzed population. Skin cancer prevailed in relation to other neoplasms and solid tumors were more diagnosed than lymphoproliferative diseases in this series of patients.
Answer:
In the 1830s, the philosophy of Transcendentalism arose in New England. Some of its most famous adherents, including Ralph Waldo Emerson and Henry David Thoreau, are still regarded as leading American thinkers today.
Explanation nothing
The main factors that contributed to the downfall of Camelot was selfishness among the knight despite that they swore to be loyal to King Arthur.
<h3>What is the
downfall of Camelot?</h3>
The downfall of Camelot was illustrated in the Movie titled "Merlin" when Uther Pendragon's reign in Camelot fell to his daughter Morgan.
In conclusion, the selfish needs of some knight before their duty was the main factor.
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