In 1681, King Charles II granted William Penn, a Quaker, a charter for the area that was to become Pennsylvania. Penn guaranteed the settlers of his colony freedom of religion. He advertised the policy across Europe so that Quakers and other religious dissidents would know that they could live there safely.
Westward expansion was a natural progression for the nation because the most powerful entities came from the East (England). It is only natural that they spread out and conquer/capture/kill/annihilate those in their way (the true Americans/Native Americans). In doing so they conquered a whole land and taught them their ways while spreading West.
Protiens in the muscle tissue transferred through blood