Deletion mutation is responsible for Tay-Sachs disease.
Explanation:
Deletion mutation may be defined as the loss of a sequence of a nucleotide base or entire deletion of chromosome at the time of DNA replication.
Tay Sachs disease is an autosomal recessive disorder and damages the central nervous system of the body. The alpha sub-unit of Hex A gene codes for the enzyme hexosaaminidase has been lost in the Tay Sachs disease.
Thus, the deletion mutation is responsible for the Tay Sachs disease.