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Lupus is a multisystem disease in which autoantibody production can lead to inflammation and tissue
damage in any part of the body. The pathogenesis of lupus is thought to be a combination of
predisposing genetic factors and environmental factors such as medication, or infectious agents that
trigger an abnormal immune response. This occurs when Suppressor T cells fail to suppress, in other words there are defects in cell signaling
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These causes include habitat modification and fragmentation, introduced predators or competitors, introduced species, pollution, pesticide use, or over-harvesting. However, many amphibian declines or extinctions have occurred in pristine habitats where the above effects are not likely to occur.
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X-linked inheritance means that the gene causing the trait or the disorder is located on the X chromosome. Women have two X chromosomes; men have one X and one Y. Genes on the X chromosome can be recessive or dominant. Their expression in females and males is not the same.