Collagen secretion by fibroblasts is the dominant cellular process that
characterizes this phase of the client's healing. At the proliferation phase of
healing, the damaged area
within the wound is rebuilt with new granulation tissue which is made up of collagen
and extracellular matrix secreted by fibroblasts. The colour and condition of
the granulation tissue indicates how the wound is healing. Dark granulation tissue
indicates infection or poor perfusion while healthy granulation tissue is
granular and uneven in texture with pink or red colour.
