The main difference between them is that house is concrete. House refers to a building in which someone lives. In contrast, a home can refer either to a building or to any location that a person thinks of as the place where she lives and that belongs to her.
A house is a building that you go to at the end of the day to sleep, but a home is the person/place you feel the most comfortable. A home is where you can be yourself without the fear of being judged or hurt. A home can be with your significant other, your best friend, or your family.
