A hormone imbalance may occur if this feedback system has trouble keeping the right level of hormones in the bloodstream, or if your body doesn't clear them out of the bloodstream properly.
It can be either diffusion, osmosis or active transport. depending on what is transported and how in which net direction they're moving.
They can confiscate the abusive drug the person if using, or admit the person to rehab, or simply apply them for therapy. They can substitute the drug for something else like say it was a cigarette, you could instead use cigarette shaped candy’s. There are quite a bit of ways to help but those are just a few.