Paliperidone has low affinity
for lipid-rich environments compared from the parent compound risperidone. Due to
its hydrophilicity characteristic, paliperidone is capable of hydrogen bonding
with other molecules containing water and hydroxyl groups. Lipophilicity is a
determining factor for the rate and degree of metabolism of the drug in the
body and for crossing the blood–brain barrier (BBB).
Moreover, these differences are
implicated in synaptic plasticity and neuronal firing effects in the mechanism
of mitochondrial movement, protein expression, and phosphorylation of the drug.
Paliperidone as a mood stabilizer is an active metabolite of risperidone with antipsychotic effects used
for the treatment of schizophrenia and its associated disorders.
What might cause this population to enter logistic growth? resources become scarce birth rate increases emigration decreases carrying capacity is increased.
Explanation:Selectively permeable means a membrane allows the passage of some molecules or ions and inhibits the passage of others. The capacity to filter molecular transport in this manner is called selective permeability
