Answer:
A:Scientific evidence must be reported, verified, and accepted by the scientific community
B:amino acid
Explanation:
aaaay another flvser
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
I think zoe because you can’t just test which one is the best it’s too broad to investigate
Answer: Option D) 1:4
Explanation:
Recall that the sum of all nitrogenous bases in the DNA nucleotide is equal to 100%. And specific base pairings of Adenine to Thymine (A=T), and Cytosine to Guanine (C=G) must be equal.
So, the percentage of Adenine equal thymine, and that of cytosine equals guanine.
Now, A + T + C + G = 100%
So, if adenine makes up 10% of the DNA nucleotides, then thymine is also 10%.
Then, 10% + 10% + C + G = 100%
20% + C + G = 100%
C + G = 100% - 20% = 80%
Thus, divide 80% by 2 to obtain the individual percentage of cytosine and guanine. Each will take 40%
Ratio Adenine to Guanine is 10% to 40%
or 1:4 in simplest form
