Answer:
At the end of 6 hours, 6 feet of the ladder remained above water
Explanation:
we are given the following:
change in tide = 8 inches per hour
1 hour = 8 inches
∴ 6 hours = 8 × 6 = 48 inches
Now, since the length of the ladder is measured in foot, let us convert the rate of tide rising to foot.
12 inches = 1 foot
dividing both sides by 12:

Therefore, after 6 hours, the tide rises by 2 feet.
Next, we are told that the rope ladder at the beginning was 8 feet, hence the length remaining above water after 6 hours of the rising of the tide is calculated as follows:
= 8 feet above water
height of tide = 2 feet = amount submerged in water
∴ length above water = (ladder before rising of the tide) - (amount submerged in water)
length above water = 8 - 2 = 6 feet
Therefore at the end of 6 hours, 6 feet of the ladder remained above water
Answer:
knowledge of the sequence product
Explanation:
A gene knockout is a technique used in molecular genetics to deactivate target genes in an organism in order to study their functions by reverse genetics (i.e., gene loss). Knockouts are generated by different methods including, for example, homologous recombination or site-specific nucleases (zinc-fingers, TALENS, CRISPR/Cas9). These techniques require to know a priori the sequence of each gene to be knocked out in order to target desired mutations. In the last years, the CRISPR/Cas9 tool has gained attention to knockout genes of interest because it is a genome editing system that can be easily used for deletion or insertion of bases.
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The most likely answer here is 1 and 4.