Question

how will knowing that Romeo and Juliet kill themselves before the story actually begins affect your reading of the play

Answer 1

It makes you feel a bit awkward, because you feel connected to the characters as you are reading, and when you know that they both die in the end, it makes you feel a little sad, because you know that it isn't necessarily going to end up happily ever after.
Hope this helps!
~Mistermistyeyed.

Answer 2

Well you need to read through it there are more deaths throughout the play that lead up to the death of romeo and Juliet.