Histamine is a chemical substance released in inflammatory and allergic responses. The histamine H1 receptor o? Histamine is a c
hemical substance released in inflammatory and allergic responses. The histamine H1 receptor on target cells is a G protein-coupled receptor that activates phospholipase C in response to the binding of histamine. Which statement about the binding of histamine to the histamine H1 receptor is false? a. Histamine binds extracellularly to the H1 receptor.
b. When histamine binds to the H1 receptor, the receptor undergoes a conformation change and binds the inactive G protein.
c. Histamine binds intracellularly to the inactive G protein, activating the G protein.
d. Once the G protein is active, it binds to the enzyme phospholipase C, activating it. e. Histamine is likely hydrophilic.
The correct answer for the question that is being presented above is this one: "b. When histamine binds to the H1 receptor, the receptor undergoes a conformation change and binds the inactive G protein." The statement about the binding of histamine to the histamine H1 receptor is false is that <span>b. When histamine binds to the H1 receptor, the receptor undergoes a conformation change and binds the inactive G protein.</span>
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