Running a marathon causes the heart rate to increase. Also, one would exert energy running, therefore resulting in sore muscles. These sore muscles are the result of lactic acid fermentation.
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The United Nations Conference on International Organization, commonly known as the San Francisco Conference, was a convention of delegates from 50 Allied nations that took place from 25 April 1945 to 26 June 1945 in San Francisco, California, United States of America.
Explanation:
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They wanted to create a government that could create a common belief among the states but not take away the states' rights of self control.
One of the major factors that allowed Native Americans in Mexico to settle cities larger than those in areas to the north was better soil, which led to better crops being harvested, which led to larger populations being sustained.
Byzantium/Constantinople was conquered in 1451, but the empire continued to decline starting around the 18th or 19th centuries. It officially died in WWI. As for how long it was a major threat to Europe, the empire's prime was the 16th century, under Suleiman the Magnificent.