Answer:
<u>A focal infection</u> is a small region of infection, from where the pathogen can move to other areas of the body to cause a secondary infection.
Explanation:
The focal infection theory is a theory that states that many chronic diseases (such as cancer, arthritis, mental illness) are caused by a focal infection. A focal infection is a small region of infection or a localized infected region, which can lead to a secondary infection at a site, which is susceptible to infections. Examples of such focal regions are nasal sinuses, kidney, gall bladder, liver, etc.
<u>Therefore,</u><u> a focal infection </u><u>can be defined as a small region of infection, from where the pathogen can move to other areas of the body to cause a secondary infection</u>.
Answer:
Delivered small RNAs can inhibit protein A production through the RNA interference (RNAi) mechanism, and thus impairs angiogenesis
Explanation:
The pregnancy-associated plasma protein-A is a protease enzyme involved in the formation of new blood vessels by increasing insulin-like growth factor I (IGF-I) bioavailability. Moreover, small RNAs (<200 nucleotides in length, generally 18 to 30 nucleotides) are non-coding RNA molecules that function in RNA silencing through the RNA interference (RNAi) pathway. Small RNAs are widely used in molecular biology laboratories because they can be delivered into specific cells in order to silence target mRNAs such as, in this case, the mRNA encoding protein A, by complementary base pairing and thereby inducing translational repression. In consequence, mRNAs complementary to delivered small RNAs are silenced through RNAi pathways, i.e., by cleavage of the target mRNA and/or mRNA destabilization.
