As the twentieth century progressed, the size of the United States Federal Government expanded dramatically. This naturally resulted in the Vice President having to take on more of the responsibilities that the President simply didn't have time to take care of.
As the scope of responsibilities of the President of the United States increased during the 20th century, the Vice-President came to be relied upon to handle greater responsibilities also.
A 21st century Vice-President, Joe Biden, said it well: “The way the world has changed, the breadth and the scope of the responsibility an American president has virtually requires a vice president to handle serious assignments, just because the president’s plate is so very full." Biden was quoted in the book, The American Vice Presidency: From Irrelevance to Power, published by Smithsonian Books in 2014.
Another point might be made about 20th century Vice-Presidents -- especially in the latter half of the century. A number of Vice-Presidents became President because of things that happened to the President. . President Franklin Roosevelt died while in office, and was succeeded by his Vice-President, Harry Truman (in 1945). Vice-President Lyndon Johnson became President when John F. Kennedy was assassinated in 1963. Gerald Ford rose from Vice-President to President when Richard Nixon resigned to avoid impeachment.
In the current situation of American politics, with partisan politics strongly dividing Congress, Vice-President Mike Pence has functioned a number of times as the tie-breaking vote in the Senate on important matters -- another way the Vice-Presidency has taken on greater responsibility lately.