Question

De novo nucleotide synthesis differs for purine and pyrimidine bases. However, some molecules are important precursors and intermediates in both pathways. Which intermediates are common to both purine and pyrimidine nucleotide synthesis? orotate formate glycine aspartate PRPP Purine bases, which have two rings, have a more complex synthetic pathway than do pyrimidine bases, which have one ring. As a result, purine synthesis requires more components than pyrimidine synthesis. Which amino acids contribute atoms to the purine structure in de novo purine synthesis? lysine aspartate glycine glutamine histidine

Answer 1

Answer:

1. Aspartate  and PRPP

2. Aspartate, glycine and glutamine

Explanation:

Aspartate is a precursor in both the synthesis of purine and pyrimidine. It aids in the formation of Carbamoyl Aspartate in pyrimidine synthesis while in purine, it contributes nitrogen 1 to the purine ring. PRPP is needed in the activation of ribose sugar in the purine nucleotide synthesis, while in that of pyrimidine, it aids in the conversion of orotate to OMP by adding  phosphate group to orotate.

Aspartate, glycine and glutamine are precursors in the de novo synthesis of purine nucleotides. Aspartate contribts nitrogen 1, glycine cotributes C4, C5 and nitrogen 7 while glutamine contributes N3 and N9.