The most impactful changes to Native American populations done by the colonial settlement was:
1 - the disease - smallpox and influenza killed almost 90% American Native population 2. extermination policies - by hunting them, the population was in decline3. Territory - the colonists took their land4. forced relocation policies - the colonits forced them to stay in some special place, no leaving, starving them5. coexistence reasoning - the differences between colonist and Native believes
Mass production of printed material. Before the press, each page of a Bible, for example, could take all day to write. After the press it would take a few days to carve the stamp, but then you could print 50 copies of the page in a very short time.
The settlers of Roanoke just disappeared and it's still a mystery.
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England is the capital of London