The answer is D. All of the above, as different changes in the environment can lead to many different things.
The answer is C. As new colonists and explorers discovered the Americas, they also brought disease. This heavily impacted the American Indians as a majority of their population suffered from epidemics.
A. foreshadowing because sensory details are touch,taste,sound,see,smell; and you can't do the majority of those with this passage. Also, there isn't a metaphor in this.