Answer:
The correct answer is "5-1-3-2-4".
Explanation:
Internalization of LDL particles into cells, is needed to form the intracellular vesicles known as endosomes. The order of events that allow for this process are:
5) LDL receptors migrate to the cell surface and cluster in clathrin-coated pits. Clathrin acts directing the receptors to the cell membrane region where endosomes are formed.
1) A combination of cholesterol and apolipoprotein binds to LDL receptors and becomes internalized as endocytotic vesicles. Once the receptors are in the proper cell membrane region, cholesterol and apolipoprotein are bound and internalized.
3) Several endocytotic vesicles fuse to form an endosome.
2) The environment of the endosome becomes acidic, which causes the LDL to dissociate from its receptor; additionally, the endosome fuses with a lysosome. LDL should be dissociated from its receptor since it is going to be degraded in the following step.
4) The LDL particle is degraded by the lysosome. This takes place after endocytosis, when LDL particles are transported into lysosomes once they are fused, cleaving the cholesterol esters into cholesterol and fatty acids.
Answer:
drinking water after a long run
Explanation:
When there arises a change or shift in the state or action of any organism because of any external stimulus, the result is said to be the response to external stimulus. The response or reaction to the external stimulus arises when the organism experiences or senses the stimulus.
Drinking water after a long run is an example of the response to external stimulus. Here, the external stimulus is the loss of water in the water because of the action of running. This makes the individual drink water which is a response to the external stimulus.
Answer:
Forethought
Explanation: Basically means planning ahead of time in order to know what to do when you are faced in a situation or event that will happen in the future
