Terrible plagues of smallpox, influenza, and other viruses.
Eugene Talmadge was an outspoken governor of Georgia and was found to be vocally criticizing F.D. Roosevelt's New Deal programs. He believed FDR was overstepping his position in forcing states to participate in New Deal programs with specifics laid out. States were required to run programs like the CCC and WPA which provided jobs for many out of work people. The biggest issue with these programs for a southern was the equal opportunity provided to blacks. Talmadge argued it should be a state's rights to employ who wished in the programs. Georgia still practiced Jim Crow segregation, literacy tests, poll taxes, and lynchings to maintain racial separation in the state.
My answer has to be 20 character long but the answer to your question is, you
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Regions in the midst of rapid transition to agricultural modernization
The region would not want to have regulations in place that would slow down the progress towards modernization.
Slavery was the main cause because the union supported equal rights so no slavery. The confederates wanted slaves so they fought to keep slaves but fortunately for the good world and unfortunately for the racist (hhm Donald Trump) the confederates lost the war.