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First of all, the Egyptians started the dog as man's best friend. A great helper and protecter of their master. If a human has a strong relationship with a dog, the dog would sacrifice to protect them, as if a mother and child.
Moving along, dogs are a skilled worker. In many cases, dogs will retrieve things. To a shot down duck or a baby trapped. They will listen to their master for instructions and and do a certain task. Many dogs are used to herd sheep or farm animals.
Macbeth says his love for Duncan overcame his reason, thus causing him to kill the guards. Macbeth says the dead King's wounds looked like "an opening in the world to let in wasteful destruction.
