Can we please see the choices, without them i won't be able to help you
Spain had once persecuted noncatholics in order to make the country uniform in religion
Columbus' explorations of the New World led to the spreading of diseases to the Americas which killed thousands of Native Americans, his efforts led to the enslavement and oppression of Native Americans through colonization, and ultimately led to the subjugation of the Native American peoples to European powers for centuries to come.
I believe the answer is B.