I think that the best answer is the geographic location: many other countries (Sweden for example) have tried being neutral at different times but did not manage to: but the fact that the US has only two boundaries, and that both other countries also have a history of fighting from independence from a European power, makes it possible that unless US decideds to get involved in international politics, it can be "left alone".
hich group most threatened the Byzantine Empire in 1050?
Ottoman Turks
Muslim Arabs
Latin Christians
Orthodox Christians